The Bree Solution

After the parking lot ambush :), I invited Daniel, Jonas, Sarah and Taylor to crash at my place. Taylor and I are looking into the documents that were dropped in the water. Daniel Jonas and Sarah have some personal issues that they need to work out. We need your help with the document, I'll post it in the forum. - Spencer





The Bree Solution on LGpedia
From LGpedia:
"Ivan Pavlov was a Russian psychologist and physician, who famously taught a dog to associate the ringing of a bell with being fed, to the point where the dog would salivate at the sound of the bell."

From the forum:

LAlabrat Posted: Wed Jul 11, 2007 8:36 pm

So this is the important letter that was in the box. Here is what we could make out:

The Bree Solution (that sounds REALLY important )
Objectives:
How to tansform Bree from TRAIT: POSITIVE to TRAIT:NEGATIVE

Given Facts:
1) Bree's blood contains a special ______ mutated and unique only to her
2) _____ for said ribozyme has a ______ hyper mutation that changes with every ___________
3) A non-function ________ exists and manifests differently in every Hymn of One ______
4) This portion still functions but you cannot ___________ because the __________ of RNA won't _______

Theoretical Solution
1) __________ in question by obtaining a sample of the that same ribozyme (?)
2) Create _____
3) Q.E.D. strand will bind to ___________

Practical Solution
1) _____ blood sample of ____
2) _____ complimentary strand _____
3) _______ with this compliementary ____
4) Q.E.D. _________

______ Reference Points
This whole section is pretty illegible.

Hopefully you all can do a better job than Taylor and I did. Thanks for your help!

Solutions:


The Bree Solution
Objectives:
How to transform Bree from TRAIT: POSITIVE to TRAIT:NEGATIVE

Given Facts:
1) Bree's blood contains a special ribozyme mutated and unique only to her
2) The gene for said ribozyme has a regulartory hyper mutation that changes with every generation.
3) A non-functioning mutated ribozyme exists and manifests differently in every Hymn of One girl
4) This portion still functions but you cannot block it because the complementary strand of RNA won't copy

Theoretical Solution
1) Block the ribozyme in question by obtaining a sample of the that same ribozyme in order to copy it
2) Create complimentary strand of RNA
3) Q.E.D. strand will bind to ribozyme and occlude its activity

Practical Solution
1) Obtain blood sample of Bree
2) Create complimentary strand of RNA
3) Inject Bree with this complementary strand
4) Q.E.D. Ribozymes blocked -rendered ineffectual


Bree Trait Reference Points
The steps concerning ribozyme function
RNAse P related -tRNA cleavage
Splicosome related - intron/exon splicing
Hammerhead related - telomere synthesis
GlmS ribozyme related - fructose 6-phosphate pathway

Also see the Character chat thread of the forum

EDIT:
I made this handy diagram to help clear up some of the technical terms found in the document.
(click image to see full size version)
~ QtheC